VACCINES COMPRISING BISPHOSPHONATE AND METHODS OF USE THEREOF

摘要

Vaccines comprise a bisphosphonate, methods for stimulating an immune response, enhancing immunogenicicty of an immunogen, and methods of treating an infection, an autoimmune disease, an allergy, and/or a cancer using the same. Liposome-encapsulated bisphosphonate treatment of non-human animals increases dendritic cell migration from the site of injection to the local draining lymph nodes, thereby increasing the antigen availability for presentation to T and B cells. Bisphosphonates directly stimulate B cell antibody secretion. Administration to a subject of a commercially available hepatitis B adult vaccine (e.g., ENGERIX B?) and free bisphosphonate increases antibody responses to the antigen present in the vaccine as compared to administration of the vaccine alone.