DIAGNOSTIC TESTS FOR IMMUNE REACTIVITY WITH HUMAN ENDOTHELIAL CELL GROWTH FACTOR
摘要
The present invention provides for methods and compositions for identifying and detecting autoantigens. Candidate autoantigens are identified by obtaining a subject sample from which HLA-DR-presented peptides are collected and identified using mass spectometry, then synthesized and reacted with the same subject peripheral blood or effected tissue. In particular, the present invention provides for endothelial cell growth factor as a novel autoantigen biomarker for Lyme disease-associated arthritis.
申请公布号
WO2012040264(A3)
申请公布日期
2012.06.14
申请号
WO2011US52456
申请日期
2011.09.21
申请人
THE GENERAL HOSPITAL CORPORATION;TRUSTEES OF BOSTON UNIVERSITY;STEERE, ALLEN C.;DROUIN, ELISE;COSTELLO, CATHERINE;SEWARD, ROBERT
发明人
STEERE, ALLEN C.;DROUIN, ELISE;COSTELLO, CATHERINE;SEWARD, ROBERT