HYALURONIC ACID-PROTEIN CONJUGATE AND METHOD FOR PREPARING SAME

摘要

The present invention relates to a hyaluronic acid-protein conjugate in which a hyaluronic acid-aldehyde derivative, in which derivative an aldehyde group is introduced to a hyaluronic acid or the salts thereof, is bound to N-terminal of a protein. The present invention also relates to a method for preparing the hyaluronic acid-protein conjugate. The hyaluronic acid-protein conjugate according to the present invention has significantly superior bio conjugation and persistent protein drug efficiency, and has excellent protein drug activity as the hyaluronic acid is specifically bound to N-terminal of a protein. In addition, an aldehyde substation rate of the hyaluronic acid-aldehyde derivative is controlled to freely control the liver-targeting properties of the hyaluronic acid, and therefore, the hyaluronic acid-protein conjugate of the present invention may be valuably used not only for drugs for treating liver diseases but also for ensuring persistent protein drug efficiency that bypass the liver. The hyaluronic acid-protein conjugate of the present invention may be valuably used for a drug delivery system of a protein.