发明名称 |
Losliche mutante CTLA4 molekule und deren verwendung. |
摘要 |
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule. |
申请公布号 |
DE122011100063(I1) |
申请公布日期 |
2012.06.14 |
申请号 |
DE201112100063C |
申请日期 |
2011.12.05 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
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分类号 |
C07K14/705;C12N15/09;A61K38/00;A61K45/00;A61P37/00;A61P37/06;C07K;C07K14/47;C07K16/00;C07K19/00;C12N5/10;C12P21/02;C12Q1/02;G01N33/68 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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