Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Further disclosed is a method for the synthesis of threose nucleic acid phosphoramidites and methods of use thereof.
申请公布号
WO2012078536(A2)
申请公布日期
2012.06.14
申请号
WO2011US63365
申请日期
2011.12.06
申请人
QUARK PHARMACEUTICALS, INC.;AVKIN-NACHUM, SHARON;FEINSTEIN, ELENA;BEIGELMAN, LEONID
发明人
AVKIN-NACHUM, SHARON;FEINSTEIN, ELENA;BEIGELMAN, LEONID