A double-specific gene expression system of neuroglia-specific and ischemia-specific genes

摘要

PURPOSE: A double-specific gene expression system for a neuroglial tissue and an ischemic tissue is provided to simultaneously recognize the tissues and to effectively treat or prevent ischemic cerebral diseases. CONSTITUTION: A double-specific recombinant vector for a neuroglial tissue and an ischemic tissue contains etythropoietin enhancer, nestin intron, promoter, and therapeutic agent for ischemic cerebral diseases. The enhancer contains a base of sequence number 1. The netin intron contains a base of sequence number 2. The promoter has an ischemic tissue-selective promoter sequence. The recombinant vector is a viral vector. A pharmaceutical composition for treating ischemic cerebral diseases contains the recombinant vector as an active ingredient.