RAPID DIFFUSION OF LARGE POLYMERIC NANOPARTICLES IN THE MAMMALIAN BRAIN

摘要

Non-adhesive particles as large as 110nm can diffuse rapidly in the brain ECS, if coated with hydrophilic coatings such as PEG coatings and preferably having neutral surface charge. The ability to achieve brain penetration with larger particles will significantly improve drug and gene delivery within the CNS since larger particles offer higher drug payload, improved drug loading efficiency, and significantly longer drug release durations.