PHARMACOLOGICAL COMPOSITION INTENDED FOR INTRA-NASAL ADMINISTRATION WITH THE AIM OF SUPPLYING A PHARMACOLOGICALLY ACTIVE COMPONENT TO THE BRAIN, AND METHOD FOR PRODUCING SAID COMPOSITION

摘要

The claimed group of inventions relates to the field of pharmacology and medicine. The pharmacological composition is intended for intra-nasal administration and enables an active substance to be supplied directly to the brain, by-passing the blood-brain barrier. The composition comprises a base container, a pharmacologically active component and a surface-modifying substance. Porous particles of an inorganic substance are used as the container, and the surface of the container is modified with surfactants, polymers or with a combination thereof. The containers made of an inorganic substance have a size in the range from 300 to 5000 nm. Inorganic substances selected from a group consisting of metal salts or oxides, for example calcium carbonate or titanium oxide, in the form of porous particles of a micron or sub-micron size, are used as the base container. For the surface-modifying substance, use is made of surfactants selected from polysorbates, or of polymers, selected from a group consisting of glycosaminoglycans, polypeptides, or combinations thereof. The method for producing the designated composition comprises producing the base container, sorbing the pharmacologically active substance in volumes of the pores in said container, and modifying the surface of said container. The base container is synthesized from inorganic substances in the form of porous particles of a micron or sub-micron size, and the surface of the designated particles of the base container is additionally modified with polymers selected from the group consisting of glycosaminoglycans or polypeptides, or with surfactants selected from the group consisting of polysorbates, or with combinations thereof.