摘要 |
The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and caninized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental. |
申请人 |
ABBOTT LABORATORIES;LACY, SUSAN E.;BARBON, JEFFREY A.;CHHAYA, MEHA;FUNG, EMMA;HUTCHINS, CHARLES W.;LANG, DIANE M.;BARLOW, EVE H.;LEDDY, MARY;CHARI, RAVI |
发明人 |
LACY, SUSAN E.;BARBON, JEFFREY A.;CHHAYA, MEHA;FUNG, EMMA;HUTCHINS, CHARLES W.;LANG, DIANE M.;BARLOW, EVE H.;LEDDY, MARY;CHARI, RAVI |