| 发明名称 |
High activity growth factor mutants |
| 摘要 |
The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction. |
| 申请公布号 |
US8188226(B2) |
申请公布日期 |
2012.05.29 |
| 申请号 |
US20060094227 |
申请日期 |
2006.11.17 |
| 申请人 |
POHL JENS;PLOEGER FRANK;KRUSE MICHAEL;BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH |
发明人 |
POHL JENS;PLOEGER FRANK;KRUSE MICHAEL |
| 分类号 |
C07K14/51;A61K38/18;C07H21/04;C12N1/21;C12N15/00;C12P21/00 |
主分类号 |
C07K14/51 |
| 代理机构 |
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代理人 |
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| 主权项 |
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