发明名称 |
ANTAGONAT COMPOSITIONS AND METHODS OF USE |
摘要 |
Provided herein are compositions, compounds, and methods of modulating gene expression. In certain embodiments described herein is a composition, wherein the composition comprises an antagoNAT. In some embodiments, the antagoNAT is an oligonucleotide comprising modified and unmodified sugar subunits, wherein the antagoNAT hybridizes with a natural antisense transcript. Certain embodiments of the present invention provide a method for modulating gene expression in a cell comprising contacting the cell with an antagoNAT. In some embodiments, the method includes forming a hybrid comprising the antagoNAT and a natural antisense transcript of the gene, wherein the hybrid sterically blocks the normal function of the natural antisense transcript. |
申请公布号 |
WO2012068340(A2) |
申请公布日期 |
2012.05.24 |
申请号 |
WO2011US61137 |
申请日期 |
2011.11.17 |
申请人 |
OPKO CURNA LLC;COLLARD, JOSEPH;KHORKOVA SHERMAN, OLGA;DE LEON, BELINDA |
发明人 |
COLLARD, JOSEPH;KHORKOVA SHERMAN, OLGA;DE LEON, BELINDA |
分类号 |
A61K31/34;A61K31/505;A61K31/506;A61K31/52;A61K31/7088;A61K48/00 |
主分类号 |
A61K31/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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