| 发明名称 |
SUBSTITUTED CARBAMOYLCYCLOALKYL ACETIC ACID DERIVATIVES AS NEP INHIBITORS |
| 摘要 |
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention. |
| 申请公布号 |
WO2012065953(A1) |
申请公布日期 |
2012.05.24 |
| 申请号 |
WO2011EP70066 |
申请日期 |
2011.11.14 |
| 申请人 |
NOVARTIS AG;KARKI, RAJESHRI GANESH;KAWANAMI, TOSHIO;KSANDER, GARY MICHAEL;LIU, QIAN;MOGI, MUNETO;SCHIERING, NIKOLAUS;SUN, ROBERT |
发明人 |
KARKI, RAJESHRI GANESH;KAWANAMI, TOSHIO;KSANDER, GARY MICHAEL;LIU, QIAN;MOGI, MUNETO;SCHIERING, NIKOLAUS;SUN, ROBERT |
| 分类号 |
C07C235/36;A61K31/192;A61K31/216;A61K31/341;A61K31/40;A61K31/437;A61K31/4402;A61P9/08;C07C235/40;C07D207/16;C07D213/55;C07D235/00;C07D257/04;C07D307/52 |
主分类号 |
C07C235/36 |
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