发明名称 CRYSTALLINE FORM OF AN INHIBITOR OF MDM2/4 AND P53 INTERACTION
摘要 A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4- methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4dihydro-2H- isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, (I).
申请公布号 CA2816810(A1) 申请公布日期 2012.05.24
申请号 CA20112816810 申请日期 2011.11.17
申请人 NOVARTIS AG 发明人 BERGHAUSEN, JOERG;REN, HAIXIA
分类号 C07D401/12;A61K31/496;A61P35/00 主分类号 C07D401/12
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