An integrated sensor that is capable of discriminating the distance of a label from the sensor without using an optical signal. The label is attached to a single probe molecule or a group of probe molecules that interacts with a single or group of target molecules. As a consequence of this interaction, the probe molecule and/or the target molecule undergo a conformal change. This conformal change leads to perturbations in the distance of the label from the sensor. Thus, measurements and properties such as the concentration and the identity of one or more target molecules can be discerned from signals generated by the sensor (or by a plurality of sensors in a sensor array) and subjected to analysis using general purpose programmable computers programmed with suitable software that controls the analytical process, and such measurements and properties can be provided as a result of the analysis.
申请公布号
WO2012068392(A2)
申请公布日期
2012.05.24
申请号
WO2011US61227
申请日期
2011.11.17
申请人
CALIFORNIA INSTITUTE OF TECHNOLOGY;PAI, ALEX, H.;CHAPMAN, STEVEN, A.;HAJIMIRI, SEYED, ALI
发明人
PAI, ALEX, H.;CHAPMAN, STEVEN, A.;HAJIMIRI, SEYED, ALI