发明名称 |
LENTIVIRAL VECTORS PSEUDOTYPED WITH A SINDBIS VIRUS ENVELOPE GLYCOPROTEIN. |
摘要 |
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain). |
申请公布号 |
MX2012001075(A) |
申请公布日期 |
2012.05.22 |
申请号 |
MX20120001075 |
申请日期 |
2010.07.22 |
申请人 |
IMMUNE DESIGN CORP.* |
发明人 |
JAMES M. ALLEN;NEAL S. VAN HOEVEN;JIN ZHONG LI;DEREK D. SLOAN;THOMAS W. DUBENSKY, JR. |
分类号 |
C07K14/18;C12N15/867 |
主分类号 |
C07K14/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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