The present invention is directed to particular antibodies and fragments thereof that find use in the detection, prevention and treatment of diseases and disorders associated with abnormal angiogenesis. In particular, these antibodies detect tumor endothelial marker 8 (TEM8) in its native and cell-surface expressed form. Also disclosed are improved methods for producing monoclonal antibodies, as well as pharmaceutical compositions and kits.
申请公布号
WO2012065161(A2)
申请公布日期
2012.05.18
申请号
WO2011US60583
申请日期
2011.11.14
申请人
SCOTT & WHITE HEALTHCARE;THE GOVERNMENT OF THE UNITED STATES OF AMERICA;WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE;FRANKEL, ARTHUR, E.;SU, YUNPENG;ST. CROIX, BRAD