发明名称 |
ACID-CLEVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS |
摘要 |
An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided. |
申请公布号 |
US2012122153(A1) |
申请公布日期 |
2012.05.17 |
申请号 |
US201113226610 |
申请日期 |
2011.09.07 |
申请人 |
BEDZYK LAURA A.;FAHNESTOCK STEPHEN R.;GRUBER TANJA MARIA;OKEEFE DANIEL P.;ROUVIERE PIERRE E.;E. I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
BEDZYK LAURA A.;FAHNESTOCK STEPHEN R.;GRUBER TANJA MARIA;OKEEFE DANIEL P.;ROUVIERE PIERRE E. |
分类号 |
C12P21/02;C07K1/00;C07K5/113;C07K7/06;C07K19/00;C12N1/19;C12N1/21 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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