High affinity HIV T cell receptors

摘要

The present invention provides TCRs having an affinity (K) of less than or equal to lµM, and/or an off-rate (k) of 1x10 S or slower, for the SLYNTVATL-HLA- A* 0201 complex PROVIDED THAT when the said TCR is presented by cell and comprises SEQ ID NOs: 1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.