FUSION PROTEIN FOR INHIBITING CERVICAL CANCER

摘要

A fusion protein for inhibiting and/or preventing cancer induced by human papillomavirus type 16 is disclosed. The fusion protein comprises: an E7 peptide sequence of human papillomavirus type 16; a Pseudomonas exotoxin A(PE) polypeptide comprising a translocating peptide; and a carboxyl terminal section comprising the amino acid sequence of KDEL, KDELRDELKDEL or SEQ ID NO: 2 located at the C-terminus of the fusion protein; in which the E7 peptide sequence is fused to the carboxyl terminal section comprising the amino acid sequence of KDEL, KDELRDELKDEL or SEQ ID NO: 2.