发明名称 |
METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN SVCAM AND/OR SMADCAM LEVELS |
摘要 |
Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (sVCAM) and/or soluble mucosal addressin cell adhesion molecule (sMAdCAM) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (PK/PD) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation. |
申请公布号 |
CA2816016(A1) |
申请公布日期 |
2012.05.10 |
申请号 |
CA20112816016 |
申请日期 |
2011.10.24 |
申请人 |
ELAN PHARMACEUTICALS, INC. |
发明人 |
CHACKERIAN, ALISSA A. |
分类号 |
G01N33/68;A61K39/395;G01N33/53;G01N33/564 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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