发明名称 |
OXYPYRIMIDINES AS SYK MODULATORS |
摘要 |
The present invention is directed to compounds of formula (I) and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which arc inhibitor of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma. |
申请公布号 |
WO2012061415(A1) |
申请公布日期 |
2012.05.10 |
申请号 |
WO2011US58822 |
申请日期 |
2011.11.01 |
申请人 |
PORTOLA PHARMACEUTICALS, INC.;PANDEY, ANJALI;XU, QING;HUANG, WOLIN;JIA, ZHAOZHONG J.;SONG, YONGHONG |
发明人 |
PANDEY, ANJALI;XU, QING;HUANG, WOLIN;JIA, ZHAOZHONG J.;SONG, YONGHONG |
分类号 |
C07D239/48;A61K31/505;A61K31/506;A61K31/513;A61P9/00;A61P29/00;A61P35/00;A61P37/00;C07D401/12;C07D403/12;C07D405/12;C07D417/12 |
主分类号 |
C07D239/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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