| 发明名称 |
PURIFIED CROCETIN COMPOUND AND METHOD FOR TREATING, INHIBITING, AND/OR PROPHYLAXIS OF CANCER, SUCH AS PANCREATIC CANCER |
| 摘要 |
<p>A fraction separated from crude crocetin by preparative HPLC, and identified using LC/MS and NMR as crocetinic acid, markedly regressed the proliferation and increased apoptosis in pancreatic cancer cells. Purified crocetinic acid showed more potency than15 commercial or crude crocetin using proliferation and apoptosis as markers. Purified crocetinic acid also showed significant anti- tumorigenic activity against pancreatic cancer cells in a mouse model of pancreatic cancer. Given crocetinic acid's low toxicity, crocetinic acid could be used as a chemotherapeutic or chemopreventative agent for pancreatic cancer.</p> |
| 申请公布号 |
WO2012060854(A1) |
申请公布日期 |
2012.05.10 |
| 申请号 |
WO2011US01735 |
申请日期 |
2011.10.07 |
| 申请人 |
U.S DEPARTMENT OF VETERANS AFFAIRS;UNIVERSITY OF KANSAS;CURATORS OF THE UNIVERSITY OF MISSOURI;DHAR, ANIMESH;GUTHEIL, WILLIAM, G. |
发明人 |
DHAR, ANIMESH;GUTHEIL, WILLIAM, G. |
| 分类号 |
A61K31/225 |
主分类号 |
A61K31/225 |
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