发明名称 |
NOVEL LIPID FORMULATIONS FOR DELIVERY OF THERAPEUTIC AGENTS TO SOLID TUMORS |
摘要 |
The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells. |
申请公布号 |
EP2449114(A1) |
申请公布日期 |
2012.05.09 |
申请号 |
EP20100793484 |
申请日期 |
2010.06.30 |
申请人 |
PROTIVA BIOTHERAPEUTICS INC. |
发明人 |
YAWORSKI, ED;REID, STEPHEN;HEYES, JAMES;JUDGE, ADAM;MACLACHLAN, IAN |
分类号 |
C12N15/88;A61K9/14;A61K31/713;A61P35/00;C07H21/00;C07H21/02;C12N15/113;C12N15/87 |
主分类号 |
C12N15/88 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|