| 发明名称 | 稳定的左卡尼汀化合物 | ||
| 摘要 | 本发明属于医药技术领域，具体涉及左卡尼汀倍半水合化合物，本发明得到的左卡尼汀倍半水合物，含有一个半结晶水，具有的优点：纯度高，稳定性好，即使在高湿度条件下吸湿增重也不明显，本发明还涉及使用这种水合物预防和减轻心肌损伤，缓解和减轻胸痛症状，治疗冠心病、心绞痛、心力衰竭、心肌梗死、脑梗死,对肾脏疾病、慢性肺原性心脏病、男子不育症、获得性免疫缺陷综合征、间歇性跛行等，以及急慢性肝炎、肝硬化、慢性肝功能不全、肌肉萎缩、糖尿病、产后子宫收缩不良的辅助治疗等。 | ||
| 申请公布号 | CN102442918A | 申请公布日期 | 2012.05.09 |
| 申请号 | CN201110343682.2 | 申请日期 | 2011.11.03 |
| 申请人 | 天津市汉康医药生物技术有限公司 | 发明人 | 严洁;黄欣 |
| 分类号 | C07C229/22(2006.01)I;C07C227/42(2006.01)I;A61K31/205(2006.01)I;A61P9/00(2006.01)I;A61P9/10(2006.01)I;A61P9/04(2006.01)I;A61P13/12(2006.01)I;A61P15/08(2006.01)I;A61P37/00(2006.01)I;A61P21/00(2006.01)I;A61P1/16(2006.01)I;A61P21/02(2006.01)I;A61P3/10(2006.01)I;A61P15/04(2006.01)I | 主分类号 | C07C229/22(2006.01)I |
| 代理机构 | 代理人 | ||
| 主权项 | 1.式Ⅰ所示左卡尼汀化合物，<img file="921621DEST_PATH_IMAGE001.GIF" wi="" he="" />（Ⅰ）用卡尔费休法测定，所述水合物含有14.26%—14.45%(重量百分比)的水分；所述左卡尼汀水合物的晶体，用CuKa射线作为特征X射线粉末测定中，其图谱具有下列2θ衍射角和D值，相对强度大于30的为：<tables num="0001"><table><tgroup cols="3"><colspec colname="c001" colwidth="20%" /><colspec colname="c002" colwidth="39%" /><colspec colname="c003" colwidth="39%" /><tbody><row><entry morerows="1">峰数</entry><entry morerows="1">2θ角（°）实测值</entry><entry morerows="1">d（）实测值</entry></row><row><entry morerows="1">1</entry><entry morerows="1">5.620</entry><entry morerows="1">15.7123</entry></row><row><entry morerows="1">2</entry><entry morerows="1">11.240</entry><entry morerows="1">7.8656</entry></row><row><entry morerows="1">3</entry><entry morerows="1">16.880</entry><entry morerows="1">5.2481</entry></row><row><entry morerows="1">4</entry><entry morerows="1">18.120</entry><entry morerows="1">4.8916</entry></row><row><entry morerows="1">5</entry><entry morerows="1">22.200</entry><entry morerows="1">4.0010</entry></row><row><entry morerows="1">6</entry><entry morerows="1">22.780</entry><entry morerows="1">3.9004</entry></row></tbody></tgroup></table></tables>相对强度大于等于10的为：<tables num="0002"><table><tgroup cols="3"><colspec colname="c001" colwidth="20%" /><colspec colname="c002" colwidth="39%" /><colspec colname="c003" colwidth="39%" /><tbody><row><entry morerows="1">峰数</entry><entry morerows="1">2θ角（°）实测值</entry><entry morerows="1">d（）实测值</entry></row><row><entry morerows="1">1</entry><entry morerows="1">5.620</entry><entry morerows="1">15.7123</entry></row><row><entry morerows="1">2</entry><entry morerows="1">9.340</entry><entry morerows="1">9.4610</entry></row><row><entry morerows="1">3</entry><entry morerows="1">10.120</entry><entry morerows="1">8.7335</entry></row><row><entry morerows="1">4</entry><entry morerows="1">11.240</entry><entry morerows="1">7.8656</entry></row><row><entry morerows="1">5</entry><entry morerows="1">11.920</entry><entry morerows="1">7.4184</entry></row><row><entry morerows="1">6</entry><entry morerows="1">14.960</entry><entry morerows="1">5.9170</entry></row><row><entry morerows="1">7</entry><entry morerows="1">15.240</entry><entry morerows="1">5.8090</entry></row><row><entry morerows="1">8</entry><entry morerows="1">15.980</entry><entry morerows="1">5.5416</entry></row><row><entry morerows="1">9</entry><entry morerows="1">16.880</entry><entry morerows="1">5.2481</entry></row><row><entry morerows="1">10</entry><entry morerows="1">17.540</entry><entry morerows="1">5.0521</entry></row><row><entry morerows="1">11</entry><entry morerows="1">18.120</entry><entry morerows="1">4.8916</entry></row><row><entry morerows="1">12</entry><entry morerows="1">18.480</entry><entry morerows="1">4.7972</entry></row><row><entry morerows="1">13</entry><entry morerows="1">19.500</entry><entry morerows="1">4.5485</entry></row><row><entry morerows="1">14</entry><entry morerows="1">22.200</entry><entry morerows="1">4.0010</entry></row><row><entry morerows="1">15</entry><entry morerows="1">22.780</entry><entry morerows="1">3.9004</entry></row><row><entry morerows="1">16</entry><entry morerows="1">23.820</entry><entry morerows="1">3.7324</entry></row><row><entry morerows="1">17</entry><entry morerows="1">25.080</entry><entry morerows="1">3.5477</entry></row><row><entry morerows="1">18</entry><entry morerows="1">25.620</entry><entry morerows="1">3.4741</entry></row><row><entry morerows="1">19</entry><entry morerows="1">25.860</entry><entry morerows="1">3.4424</entry></row><row><entry morerows="1">20</entry><entry morerows="1">28.340</entry><entry morerows="1">3.1466</entry></row><row><entry morerows="1">21</entry><entry morerows="1">30.760</entry><entry morerows="1">2.9043</entry></row><row><entry morerows="1">22</entry><entry morerows="1">32.020</entry><entry morerows="1">2.7928</entry></row></tbody></tgroup></table></tables>2θ衍射角的误差为±0.2。 | ||
| 地址 | 300203 天津市河西区大沽南路敬重里4号3层 | ||