Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling

摘要

Methods for screening compounds that modulate umami taste signaling in taste cells are provided. These methods comprise contacting a compound with hetero-oligomeric taste transduction G-protein coupled receptors that respond to umami taste stimuli, and determining whether the compound binds to and/or affects the activity of the hetero-oligomeric umami receptor.