NON-INVASIVE FETAL GENETIC SCREENING BY SEQUENCING ANALYSIS
摘要
The invention provides a non-invasive technique for the differential detection of multiple genotypes and/or mutations for a plurality of target genes in a biological sample containing genetic material from different genomic sources. Methods are conducted using multiplex amplification of a plurality of target sequences from the biological sample, and sequencing is used to detect and enumerate genetic mutations and chromosomal abnormalities at the single nucleotide level.
申请公布号
WO2012058316(A1)
申请公布日期
2012.05.03
申请号
WO2011US57897
申请日期
2011.10.26
申请人
STANFORD UNIVERSITY;QUAKE, STEPHEN, R.;GU, WEI;FAN, HEI-MUN, CHRISTINA
发明人
QUAKE, STEPHEN, R.;GU, WEI;FAN, HEI-MUN, CHRISTINA