IRON OXIDE NANOPARTICLES IN WHICH GLUCONIC ACID AND NON-POLYMERIZED BIOLOGICAL MATERIAL ARE INTRODUCED AS SURFACE MODIFIER, SECURING IMPROVED BIOCOMPATIBILITY BY OPTIMUM INTRODUCTION OF GLUCONIC ACID, AND COMPOSITION FOR DIAGNOSING AND TREATING CANCE

摘要

The present invention relates to iron oxide-based nanoparticles comprising: an iron oxide-based central particle; a shell coated with a water-soluble material selected from the group consisting of ATP, NAD, ADP, AMP and NADP which are non-polymerized; and gluconic acid securing binding amounts and binding conditions to ensure the optimum biocompatibility on the surface of the shell, a preparation method thereof, and a contrast medium and a composition for diagnosis and treatment of cancer, containing the same. The iron oxide-based nanoparticles surface-modified with gluconic acid of the present invention reduces a degree removed through uptake by the reticuloendothelial system, thereby improving delivery to a target organ or lesion, and can be used as a contrast medium for diagnosis and treatment capable of simultaneous imaging and treatment.