发明名称 |
Trypsin-like serine protease inhibitors, and their preparation and use |
摘要 |
The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive. |
申请公布号 |
AU2007308421(B2) |
申请公布日期 |
2012.05.03 |
申请号 |
AU20070308421 |
申请日期 |
2007.10.24 |
申请人 |
THE MEDICINES COMPANY (LEIPZIG) GMBH |
发明人 |
DAGHISCH, MOHAMMED;SOFFING, ANETT;SCHWEINITZ, ANDREA;STURZEBECHER, JORG;REICHELT, CLAUDIA;STEINMETZER, PETER;VAN DE LOCHT, ANDREAS;NICKLISCH, SILKE;STEINMETZER, TORSTEN;SCHULZE, ALEXANDER;HEINICKE, JOCHEN;LUDWIG, FRIEDRICH-ALEXANDER |
分类号 |
C07C311/33;A61K31/18;A61K31/44;A61P7/02;C07D213/56;C07D213/89;C07D233/64 |
主分类号 |
C07C311/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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