| 摘要 |
A pharmaceutical composition for the sublingual delivery of an opioid comprising an opioid and ethanol, wherein the composition is comprised within a container such that the material of the container that is in contact with the composition is cyclic olefin copolymer (COC). Preferably, the opioid is methadone and is not fentanyl. The composition may further include glycerol. Preferably the container comprises a delivery device to dispense the composition in a single discharge as a spray. The delivery device may further include seals and/or plungers formed from bromobutyl polymer. The composition is preferably for use in the treatment of pain, inducing or maintaining anaesthesia, treating opioid dependence, treating anxiety, treating cough or treating diarrhoea. |
