发明名称 |
A PROCESS FOR THE PREPARATION OF EPOTHILONE ANALOGS AND INTERMEDIATES |
摘要 |
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
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申请公布号 |
CA2404212(C) |
申请公布日期 |
2012.05.01 |
申请号 |
CA20012404212 |
申请日期 |
2001.03.12 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
LI, WEN SEN;THORNTON, JOHN E.;GUO, ZHENRONG;SWAMINATHAN, SHANKAR |
分类号 |
C07D417/06;C07D491/044;A61K31/427;A61P9/10;A61P17/06;A61P19/02;A61P25/00;A61P27/02;A61P35/00;A61P35/02;C07B61/00;C07D277/30;C07D303/38;C07D491/04 |
主分类号 |
C07D417/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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