| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an improved AOX1 promoter having improved properties to facilitate downstream processing in protein production, increase time-space yield and improve quality of product. <P>SOLUTION: There is provided a wild type Pichia pastoris AOX1 promoter comprising at least one mutation selected from the group consisting of (a) a transcription factor binding site (TFBS), (b) mutated specific sequences of the wild type Pichia pastoris AOX1 promoter, and combinations thereof. <P>COPYRIGHT: (C)2012,JPO&INPIT |
