发明名称 BENZIMIDAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
摘要 The invention relates to compounds of formula (I) wherein R1 represents aryl, which is unsubstituted, or mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, and trifluoromethyl; R2 represents hydrogen, or —CO—R21; R21 represents (C1-5)alkyl, (C1-3)fluoroalkyl, or (C3-6)cycloalkyl; m represents the integer 2, or 3; p represents the integer 2 or 3; and R3 represents hydrogen, or (C1-5)alkyl; and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.
申请公布号 ZA201008448(B) 申请公布日期 2012.04.25
申请号 ZA20100008448 申请日期 2010.11.24
申请人 ACTELION PHARMACEUTICALS LTD 发明人 HUBLER FRANCIS;HILPERT KURT;RENNEBERG DORTE
分类号 A61K;A61P;C07D 主分类号 A61K
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