发明名称 |
Outer membrane vesicles and uses thereof |
摘要 |
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection. |
申请公布号 |
US8163295(B2) |
申请公布日期 |
2012.04.24 |
申请号 |
US201113211977 |
申请日期 |
2011.08.17 |
申请人 |
BOS MARTINE PETRONELLA;POOLMAN JAN;TEFSON BORIS;TOMMASSEN JOHANNES PETRUS MARIA;GLAXOSMITHKLINE BIOLOGICALS S.A.;UNIVERSITY OF UTRECHT |
发明人 |
BOS MARTINE PETRONELLA;POOLMAN JAN;TEFSON BORIS;TOMMASSEN JOHANNES PETRUS MARIA |
分类号 |
A61K39/095;A61K35/74;C07K14/22;C07K14/315;C07K16/12 |
主分类号 |
A61K39/095 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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