发明名称 |
HUMANE MONOKLONALE ANTISTOFFER MOD CD20 |
摘要 |
Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |
申请公布号 |
DK1558648(T3) |
申请公布日期 |
2012.04.23 |
申请号 |
DK20030809145T |
申请日期 |
2003.10.17 |
申请人 |
GENMAB A/S |
发明人 |
TEELING, JESSICA;RUULS, SIGRID;GLENNIE, MARTIN;VAN DE WINKEL, JAN, G., J.;PARREN, PAUL;PETERSEN, JORGEN;BAADSGAARD, OLE, D., M., SC.;HUANG, HAICHUN |
分类号 |
C07K16/28;C07K16/30;C07K16/42;C12N5/22;C12N5/24;C12N15/63 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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