| 摘要 |
A process for preparation ofα-ketoglutaric acid, which is adapted for preparing L-arginineα-ketoglutarate 1:1 and 2:1, comprising the steps of: (a) reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain dimethyl 2,2-dichloroglutarate; (b) reacting the dimethyl 2,2-dichloroglutarate from step (a) with hydroxide solution to obtain crudeα-ketoglutaratic acid aqueous solution; (c) purifying the crudeα-ketoglutaratic acid aqueous solution to obtain purifiedα-ketoglutaratic acid aqueous solution; and (d) adjusting a concentration of the purifiedα-ketoglutaratic acid aqueous solution by adding water, thereby a yield of the purifiedα-ketoglutaratic acid aqueous solution is approximately 75%. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.
|
