发明名称 |
METHOD FOR QUANTIFYING AMPLITUDE OF A RESPONSE OF A BIOLOGICAL NETWORK |
摘要 |
One or more measurement signatures are derived from a knowledge base of casual biological facts, where a signature is a collection of measured node entities and their expected directions of change with respect to a reference node. The knowledge base may be a directed network of experimentally-observed casual relationships among biological entities and processes, and a reference node represents a perturbation. A degree of activation of a signature is then assessed by scoring one or more "differential" data sets against the signature to compute an amplitude score. The amplitude score quantifies fold-changes of measurements in the signature. In one particular embodiment, the amplitude score is a weighted average of adjusted log-fold changes of measured node entities in the signature, wherein an adjustment applied to the log-fold changes is based on their expected direction of change. In an alternative embodiment, the amplitude score is based on quantity effects. |
申请公布号 |
WO2011153200(A3) |
申请公布日期 |
2012.04.19 |
申请号 |
WO2011US38703 |
申请日期 |
2011.06.01 |
申请人 |
SELVENTA, INC. |
发明人 |
THOMSON, TY, MATTHEW;LADD, WILLIAM, M.;PRATT, DEXTER, ROYDON |
分类号 |
G06F19/00;G06F9/44;G06F17/10 |
主分类号 |
G06F19/00 |
代理机构 |
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