发明名称 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
摘要 The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites and prodrugs thereof.
申请公布号 US2012093891(A1) 申请公布日期 2012.04.19
申请号 US201113333526 申请日期 2011.12.21
申请人 YAN JOHN;ZHENG XIAOXIA;BHAT VINAYAK D.;ELIXIR MEDICAL CORPORATION 发明人 YAN JOHN;ZHENG XIAOXIA;BHAT VINAYAK D.
分类号 A61K31/436;A61F2/02;A61F2/82;A61K9/00;A61M25/00;A61M25/10;A61P7/02;A61P29/00;A61P35/00;A61P37/06;B82Y5/00;C07D498/16 主分类号 A61K31/436
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