发明名称 |
4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-{[4-(N,N-DIMETHYLAMINO)-1-OXO-2-BUTEN-1-YL]AMINO}-7-((S)-TETRAHYDROFURAN-3-YLOXY)-QUINAZOLINE DIMALEATE AND THE USE THEREOF |
摘要 |
The invention provides the compound 4-[(3-chloro-4- fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7- ((S)- tetrahydrofuran-3-yloxy)-quinazoline dimaleate. The compound may be used for treatment of a benign or malignant tumour, for preventing or treating a disease of the respiratory tract and lungs or for treating a disease of the gastro-intestinal tract, or the bile duct and gall bladder. The invention also provides a process for preparing a dimaleate of 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1- oxo-2- buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline, comprising: converting 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-buten-1- yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline into the dimaleate by reacting with maleic acid in a suitable solvent, with heating.
|
申请公布号 |
CA2759063(C) |
申请公布日期 |
2012.04.17 |
申请号 |
CA20042759063 |
申请日期 |
2004.10.12 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
RALL, WERNER;SOYKA, RAINER;KULINNA, CHRISTIAN;SCHNAUBELT, JUERGEN;SIEGER, PETER |
分类号 |
C07D405/12;A61K31/505;A61K31/517 |
主分类号 |
C07D405/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|