THE SILICA MONOLITHIC PARTICLES, THE CHROMATOGRAPHIC STATIONARY PHASE COMPRISING THEM, AND THEIR MANUFACTURING METHOD

摘要

This invention is about silica monolithic particles, chromatographic stationary phases comprising them, and their manufacturing methods. The manufacturing process of silica monolithic particles of this invention includes three steps: the step for formation of bulk monolith (step 1) through sequential heating at three different temperatures, the step for powdering the silica monolith (step 2), and the step for calcination of the powdered silica monolith at 400-800 oC (step 3). In this invention, the manufacturing process for silica monolith particles becomes much simpler by removing the sieving and washing steps in comparison with the previous methods, causing great reduction of production cost. In addition, silica monolith particles with reduced average particle size and increased average pore size are obtained in this invention. Thus the stationary phases comprising the silica monolith particles of this invention result in high separation performance in liquid chromatography.