| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for covalently linking proteins and polysaccharides to form conjugate vaccines comprising a reaction between carbonyl-containing groups and amino-oxy functional groups. <P>SOLUTION: The method for preparing a conjugate comprising a process of combining an amino-oxy homofunctional or heterofunctional reagent with an entity chosen from polysaccharides, oligosaccharides, carbohydrates, and carbohydrate-containing molecules containing at least one carbonyl group, to form a polysaccharide, oligosaccharide, carbohydrate, or carbohydrate-containing molecule functionalized via at least one oxime linkage. The functionalized compound is reacted either directly or indirectly with a protein moiety to form a protein-carbohydrate conjugate that may be used as a vaccine. <P>COPYRIGHT: (C)2012,JPO&INPIT |
