| 摘要 |
A process for producing an optically active cyclopropane compound represented by the formula (4):
wherein R 3 , R 4 , R 5 and R 6 are the same or different, and represent a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, and so on; and R 7 represents a C1-6 alkyl group; and * represents an asymmetric carbon atom,
which comprises reacting a prochiral olefin represented by the formula (2):
wherein R 3 , R 4 , R 5 , and R 6 are as described above, with a diazoacetic acid ester represented by the formula (3):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒN 2 CHCO 2 R 7 €ƒ€ƒ€ƒ€ƒ€ƒ(3)
wherein R 7 is as defined above, in the presence of an asymmetric copper complex prepared from an optically active cycloalkylidenebisoxazoline compound represented by the formula (1):
wherein R 1 represents a hydrogen atom, a C1-6 alkyl group, and so on; R 2 represents a C1-6 alkyl group and so on; and n represents an integer of 0 to 3; provided that, two R 1 s may be bonded each other together with the carbon atom to which they are bonded to form a ring; and * represents an asymmetric carbon atom,
and a copper compound, is provided.
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