发明名称 |
Modulators of the ABC transporter family and methods for their use |
摘要 |
An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and mimetics thereof are provided. Also provided is a method for inhibiting expression of ABC transmembrane proteins in cells by administering to the cells the isolated factor or protein or active fragment thereof or a mimetic thereof. Such methods are useful in the enhancing delivery of small molecule therapeutic agents to the CNS and in treating cancers, particularly multidrug resistant cancers, and secretory diarrhea. In addition, compositions, methods for identifying compositions and methods for use of compositions that inhibit suppression of ABC transmembrane protein expression or reduce epoxide hydrolase activity by this factor are provided. Such compositions and methods are useful in treatment of cystic fibrosis. |
申请公布号 |
US8153597(B2) |
申请公布日期 |
2012.04.10 |
申请号 |
US20100712336 |
申请日期 |
2010.02.25 |
申请人 |
STANTON BRUCE;O'TOOLE, JR. GEORGE;SWIATECK-URBAN AGNIESZKA;MACEACHRAN DANIEL P.;MARQUIS SOPHIE MOREAU;TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
STANTON BRUCE;O'TOOLE, JR. GEORGE;SWIATECK-URBAN AGNIESZKA;MACEACHRAN DANIEL P.;MARQUIS SOPHIE MOREAU |
分类号 |
A61K38/16;A61K38/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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