IMMUNOMODULATORY NUCLEIC ACID COMPOSITION COMPRISING CHITOSAN NANOPARTICLES

摘要

A tolerogenic formulation is provided comprising a particle-forming polysaccharide coupled to a nucleic acid that encodes a therapeutic protein. A method of treating a disease or condition in a mammal that required protein therapy is also provided, such as hemophilia, comprising administering such a tolerogenic formulation to the mammal, wherein the formulation expresses a target therapeutic protein, such as FVIII or FIX.