Disclosed are methods used to diagnose Alzheimer's disease (AD) in a subject. The methods involve determining the amount of chemokine receptor 6 (CCR6) expressed in a biological sample. Expression of CCR6 in the sample that exceeds a threshold level of expression signifies that the subject has AD, even if the subject has not yet developed symptoms of AD. The methods may also be used to monitor the effectiveness of an AD treatment. Kits that facilitate the use of the methods are also disclosed.
申请公布号
WO2012006056(A3)
申请公布日期
2012.04.05
申请号
WO2011US42114
申请日期
2011.06.28
申请人
OREGON HEALTH & SCIENCE UNIVERSITY;OFFNER-VANDENBARK, HALINA;QUINN, JOSEPH F.;SUBRAMANIAN, SANDHYA
发明人
OFFNER-VANDENBARK, HALINA;QUINN, JOSEPH F.;SUBRAMANIAN, SANDHYA