METHODS OF OBTAINING CELL POPULATIONS ENRICHED WITH DESIRED CELLS

摘要

The present disclosure provides a method comprising providing a population of cells comprising a target type of differentiated cells having a pre-identified cytoskeletal profile and at least one cell selected from the group consisting of undifferentiated cells, differentiating cells and differentiated cells being different from the target type of differentiated cells; and incubating the population of cells with a cytotoxic agent, in an amount and for a time period effective to form a modified population of cells comprising predominantly or consisting essentially of the target type of differentiated cells. In one embodiment, the pre-identified cytoskeletal profile comprises presence of class III ?-tubulin on neuronal cells and the population of cells comprise neural cells and neuronal cells, the latter "surviving" the treatment in accordance with the invention.