| 发明名称 |
ANTI-IL12RBETA1 ANTIBODIES AND THEIR USE IN TREATING AUTOIMMUNE AND INFLAMMATORY DISORDERS |
| 摘要 |
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/1L18 induced IFNγproduction of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγproduction, IL12 and/IL23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders. |
| 申请公布号 |
US2012082681(A1) |
申请公布日期 |
2012.04.05 |
| 申请号 |
US201113252721 |
申请日期 |
2011.10.04 |
| 申请人 |
CARBALLIDO HERRERA JOSE M.;HARTLE STEFAN;HEUSSER CHRISTOPH;KLAGGE INGO;POLZER ANDREA;SCHWAERZLER CHRISTOPH;WOCHNIK-VELTRUP GABRIELA;NOVARTIS AG |
发明人 |
CARBALLIDO HERRERA JOSE M.;HARTLE STEFAN;HEUSSER CHRISTOPH;KLAGGE INGO;POLZER ANDREA;SCHWAERZLER CHRISTOPH;WOCHNIK-VELTRUP GABRIELA |
| 分类号 |
A61K39/395;A61P1/00;A61P17/06;A61P29/00;A61P37/00;C07K16/24;C12N5/10;C12N15/13;C12N15/63;C12P21/00 |
主分类号 |
A61K39/395 |
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