发明名称 |
TREATMENT OF B-CELL LYMPHOMA WITH MICRORNA |
摘要 |
The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL. |
申请公布号 |
WO2012041959(A1) |
申请公布日期 |
2012.04.05 |
申请号 |
WO2011EP66980 |
申请日期 |
2011.09.29 |
申请人 |
UNIVERSITY OF ZURICH;CRAIG, VANESSA;MUELLER, ANNE |
发明人 |
CRAIG, VANESSA;MUELLER, ANNE |
分类号 |
C12N15/113;A61K31/7105;A61P35/00 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|