摘要 |
There is provided a composition comprising: (a) a modified vaccinia virus ankara (MVA) vector, wherein said MVA vector comprises a nucleic acid sequence encoding an antigen; and (b) an adjuvant comprising a saponin, or an emulsion. There is also provided a composition comprising:(a) an adenovirus vector, wherein said adenovirus vector comprises a nucleic acid sequence encoding an antigen, and wherein the adenovirus is selected from: a group B adenovirus, a group C adenovirus, and a group E adenovirus; and (b) an adjuvant comprising a saponin, or an emulsion; wherein the group B adenovirus is not an adenovirus 35, the group C adenovirus is not Ad5 having an intact E3 gene region, and the group E adenovirus is not an adenovirus C7. Also provided are corresponding uses of the compositions in medicine. |
申请人 |
ISIS INNOVATION LIMITED;DE CASSAN, SIMONE;DOUGLAS, ALEXANDER;DRAPER, SIMON;FORBES, EMILY;GOODMAN, ANNA;HILL, ADRIAN;MILICIC, ANITA;REYES-SANDOVAL, ARTURO |
发明人 |
DE CASSAN, SIMONE;DOUGLAS, ALEXANDER;DRAPER, SIMON;FORBES, EMILY;GOODMAN, ANNA;HILL, ADRIAN;MILICIC, ANITA;REYES-SANDOVAL, ARTURO |