发明名称 |
RECOMBINANT POLYPEPTIDES FOR MEMBRANE FUSION AND USES THEREOF |
摘要 |
Disclosed is a recombinant polypeptide for facilitating membrane fusion. The recombinant polypeptide having a sequence with at least 80% sequence identity with the ectodomain of p14 fusion-associated small transmembrane (FAST) protein and having a functional myristoylation motif, a transmembrane domain from a FAST protein and a sequence with at least 80% sequence identity with the endodomain of p15 FAST protein. A targeting ligand can be added to the recombinant polypeptide for selective fusion. The recombinant polypeptide can be included in the membrane of a liposome, or the like, to facilitate the delivery of bioactive compounds, such as siRNA, or the recombinant polypeptide can be mixed with a lipid carrier and added to cultured cells to induce cell-cell fusion and heterokaryon formation.
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申请公布号 |
CA2813300(A1) |
申请公布日期 |
2012.04.05 |
申请号 |
CA20112813300 |
申请日期 |
2011.09.29 |
申请人 |
INNOVASCREEN INC. |
发明人 |
DUNCAN, ROY;CLANCY, EILEEN KATHRYN;LEWIS, JOHN;DE ANTUENO, ROBERTO JUSTO;NESBITT, RAE-LYNN |
分类号 |
C07K14/14;A61K47/42;C07K17/04;C12N15/02;C12N15/113;C12N15/46;C12N15/88 |
主分类号 |
C07K14/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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