发明名称 |
Stabilized and lyophilized formulation of anthracycline compounds |
摘要 |
<p>The present invention provides a lyophilized amrubicin formulation and a process thereof. In the process, the concentration of the aqueous solution before lyophilization is controlled to about 7.5 mg(potency)/mL or more. Thus, the formulation decreases the production of desaccharified compound and is stable to storage for a long period. The formulation is useful as a cancer chemotherapeutic agent.</p> |
申请公布号 |
EP2436386(A1) |
申请公布日期 |
2012.04.04 |
申请号 |
EP20090845198 |
申请日期 |
2009.05.27 |
申请人 |
DAINIPPON SUMITOMO PHARMA CO., LTD. |
发明人 |
HIROFUJI, HAJIMU;HASHIMOTO, HOTAKA;TANAKA, KAZUNARI |
分类号 |
A61K31/7004;A61K9/19;A61K31/198 |
主分类号 |
A61K31/7004 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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